Synthesis and Characterization of New Cholinium-based Ionic Liquids for Antimicrobial Application
Journal of Advanced Research in Fluid Mechanics and Thermal Sciences
Volume 42 No. 1, February 2018, Pages 16-23
Khairulazhar Jumbri1,2,*, Nor Suzy Farahana Mah Noh3, Nur Afiqah Ahmad2, Mohd Basyaruddin Abdul Rahman3, Haslina Ahmad3,*
1Centre of Research in Ionic Liquids, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia
2Department of Fundamental and Applied Sciences, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia
3Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
*Corresponding author: firstname.lastname@example.org
*Corresponding author: email@example.com
Antimicrobial, cholinium, ionic liquids, neutralization reaction
A series of new cholinium-based ionic liquids (ILs) was synthesized by using simple neutralization reaction. The synthesized ILs were choline 3,5-dinitrosalicylate, choline gallate, choline s-(+)-2-(4-isobutylphenyl)propionate, choline behenate and choline peracetate. All the synthesized cholinium-based ILs were characterized by using FT-IR, ¹H and ¹³C NMR, mass spectrometry, thermogravimetric and differential scanning calorimetry. Result obtained from all characterization techniques confirmed the formation of these cholinium-based ILs. These ILs were then tested for their antimicrobial properties. Anti-microbial test was carried out towards seven types of bacteria which consist of three Gram-positive bacteria, Bacillus subtilis (B29), Staphylococcus aureus (S276), Staphylococcus epidermidis (S273), two Gram-negative bacteria, Pseudomonas aeruginosa (ATCC 15442) and Escherichia coli (E266) and two types of yeasts, Candida albicans (9002) and Candida tropicalis (A3). Streptomycin and Nystatin were used for all bacteria as standard. There is one cholinium-based IL shows excellent inhibition of microbes from growth. Choline peracetate was found to inhibit Candida albicans (9002) as good as the standard, Streptomycin which perform highest of inhibition zone diameter, 25 mm.
CITE THIS ARTICLE
Jumbri, Khairulazhar, et al. “Synthesis and Characterization of New Cholinium-based Ionic Liquids for Antimicrobial Application.” Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 42.1 (2018): 16-23.
Jumbri, K., Mah Noh, N. S. F., Ahmad, N. A., Abdul Rahman, M. B., & Ahmad, H. (2018). Synthesis and Characterization of New Cholinium-based Ionic Liquids for Antimicrobial Application. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences, 42(1), 16-23.
Jumbri, Khairulazhar, Nor Suzy Farahana Mah Noh, Nur Afiqah Ahmad, Mohd Basyaruddin Abdul Rahman, and Haslina Ahmad. “Synthesis and Characterization of New Cholinium-based Ionic Liquids for Antimicrobial Application.” Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 42, no. 1 (2018): 16-23.
Jumbri, K., Mah Noh, N.S.F., Ahmad, N.A., Abdul Rahman, M.B. and Ahmad, H., 2018. Synthesis and Characterization of New Cholinium-based Ionic Liquids for Antimicrobial Application. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences, 42(1), pp.16-23.
Jumbri, K, Mah Noh, NSF, Ahmad, NA, Abdul Rahman, MB, Ahmad, H. Synthesis and Characterization of New Cholinium-based Ionic Liquids for Antimicrobial Application. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences. 2018;42(1):16-23.
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