Numerical Investigation of Drag Force on Micro-sized Magnetic Beads in Microchannel with Chamber Design

Journal of Advanced Research in Fluid Mechanics and Thermal Sciences
Volume 57, No. 2, May 2019, Pages 186-201

Muhammad Asnawi Vaea1, Ummikalsom Abidin1,*, Natrah Kamaruzaman1, Fazila Mohd Zawawi1, Muhammad Noor Afiq Witri Muhammad Yazid1

1 Department of Thermofluids Engineering, School of Mecahnical Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
*Corresponding author: ummi@utm.my

Cite this articleMLA
Muhammad Asnawi, Vaea, et al. "Numerical Investigation of Drag Force on Micro-sized Magnetic Beads in Microchannel with Chamber Design." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 57.2 (2019): 186-201.
APA
Muhammad Asnawi, V., Ummikalsom, A., Natrah, K., Fazila, M. Z., & Muhammad Noor Afiq Witri, M. Y.(2019). Numerical Investigation of Drag Force on Micro-sized Magnetic Beads in Microchannel with Chamber Design. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences, 57(2), 186-201.
Chicago
Muhammad Asnawi Vaea, Ummikalsom Abidin, Natrah Kamaruzaman, Fazila Mohd Zawawi, and Muhammad Noor Afiq Witri Muhammad Yazid."Numerical Investigation of Drag Force on Micro-sized Magnetic Beads in Microchannel with Chamber Design." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences. 57, no. 2 (2019): 186-201.
Harvard
Muhammad Asnawi, V., Ummikalsom, A., Natrah, K., Fazila, M.Z., Muhammad Noor Afiq Witri, M.Y., 2019. Numerical Investigation of Drag Force on Micro-sized Magnetic Beads in Microchannel with Chamber Design. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 57(2), pp. 186-201.
Vancouver
Muhammad Asnawi V, Ummikalsom A, Natrah K, Fazila MZ, Muhammad Noor Afiq Witri MY. Numerical Investigation of Drag Force on Micro-sized Magnetic Beads in Microchannel with Chamber Design. Journal of Advanced Research in Fluid Mechanics and Thermal Sciences. 2019;57(2): 186-201.

KEYWORDS

Drag force; micro-sized bead; flow rate; microchannel; trapping chamber; microfluidics

ABSTRACT

Biological cells or bioparticles separation is a primary step in most biological studies. One of the microfluidic bioparticles separation methods is the magnetic-based method. Integrated microfluidic magnetic bioparticle separation device is made up of a microfluidics channel and a magnetic system. From past studies, the design of the microfluidic channel is least discussed in comparison with the magnetic system. To fill this gap, this study has focused on numerical simulation of a microfluidic channel with chamber design and the drag forces experienced by the magnetic beads. Simulation of the microfluidics channel was done with ANSYS Fluent software. The width ratios of trapping chamber and main channel ranged from 1 to 20, the flow rates ranged from 1 ?L/min to 100 ?L/min, and the bead sizes ranged from 5 ?m to 25 ?m were used in the numerical investigation. It was discovered that as the width ratio between the trapping chamber and main channel increases, the maximum velocity decreases, causing the Reynold’s number to decrease. The pressure drop become greater at higher flow rate. Higher width ratio caused the drag force to reduce at a constant microbead size. At a constant width ratio between the trapping chamber and main channel, larger microbead sizes caused larger drag force. The microfluidic system with width ratio of 20 and flow rate of 1 ?L/min produced the lowest drag force, 3.64 x ?10?^4 pN. Since particle trapping would occur when the magnetic force is larger than the drag force, therefore a high gradient magnetic system which offered high magnetic force was proposed to be integrated with the microfluidics system.

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