Anti-Cancer Potential of Pseuduvaria Macrophylla in Human Cancer Cell Lines

Abstract

This is a short report on the recent investigation on the anticancer and antioxidant potential of Pseuduvaria macrophylla stem bark and leaf extract on human breast cancer cell (MCF-7), human prostate cancer cell (PC-3) and human colon cancer cell (HT29). LCMS experiment was done to identify the chemical composition in the methanolic extracts while GCMS analysis was done to determine the chemical composition in the hexanolic extracts. For antioxidant activity, the most active extract was leaf methanolic with 69.22 % of DPPH inhibition. Additionally, the leaf methanolic extract inhibited the better proliferation especially on human breast cancer cell (MCF-7) compared to hexane crude extracts due to more than 90% of cancer cell death and lowest IC50 value at range of 80.70 µg/mL ± 0.08 – 106.70 µg/mL ± 0.07. The major detected compounds were ?-Cadinol, neophytadiene, palmitic acid, linoleic acid, oleic acid and isopolycerasoidal and isopolycerasoidal methyl ester. The findings of this study support the anti-cancer claims of Pseuduvaria macrophylla leaf.